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Liver retransplantation in adults: indications and outcomes. Analysis of a 23-year experience in a single center in Argentina

Abstract

Background Liver retransplantation (re-LT) represents the only treatment for patients with irreversible graft failure. The aim of the current study was to describe the outcomes of both, patient and graft, after re-LT, at a high-volume referral center.

Methods Our population consisted of patients, with liver disease, who underwent re-LT in our institution between January 1996 and December 2019.

Results 49 patients met the inclusion criteria. The patient’s overall survival (OS) for the first year was 85% (Confidence Intervals (CI) 71-92) and 70% at five years (CI 53-82). In our population, three (6.12%) patients presented loss of graft and were included again in the transplant list; of these, one agreed to a new transplant while the remaining two died. This gave us graft survival results similar to those obtained for the re-LT patient; 85% at one year (CI 71-92) and 70% at 5 years (CI 53-82).

Conclusion Our study shows that re-LT is a valid and safe treatment for both early graft dysfunction and for transplanted patients who again present end-stage liver disease, showing a satisfactory long-term evolution, with parameters comparable to primary transplantation.

Keywords: Liver transplantation; Outcomes; Surgery; Liver disease
Copyright © 2022 Rocio Bruballa, Diego Sanchez Thomas, Eduardo de Santibañes, Miguel Ciardullo, Juan Mattera, Juan Pekolj, Martín de Santibañes, Victoria Ardiles. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.